作者观察了静推20％甘露醇时兔耳缘静脉的影响。病理结果显示，注射2次时甘露醇与生理盐水组无明显差别，而注射4次及8次时，在穿刺部位及里穿刺点1cm处，甘露醇组血管及其周围组织病理损害加重。主要表现为血管空增厚，内皮细胞破坏，血管内沥血，周围组织炎症及水肿等。注射8次自然恢复5天及10天的结果显示，两组恢复程度基本一致，主要为周围组织炎症及水肿的消失。本研究结果提示，甘露醇更容易导致血管损害且不易恢复，因此不宜在同一部位反复注射，其机制可能与甘露醇的高渗性有关。

The author observed the effects for rabbits’auricle vein with 2O % mannite intravenous injection. Pathological result showed: there is not obvious difference between two groups of mannite and normal saline injectde twice. but four times and eight times injection of mannite cou1d cause peripheral vein and tissues pathological damage seriously at the site of puncture and 1cm from it. It appeared thicken 0f vessel wall. damage of endothelid cell. intravascular coagulation, inflammation and hydlrops of peripheral tissues etc. The result that injected eight times with naturally recovering five to ten days showed: The recovery level of two groups was basically equal. The main appearances were diminish ment of inflammation and hydrops. The study indicated: Mannite likely cause vessel damage and not easy recovery. So it isn’t suitable for injecting at the same point repeatedly. the mechanism might related with mannite’s hypertonicity.